Leucovorin: A Promising New Therapy Now Offered at Reign-Bow Brain Treatment Center

A New Addition to Our Evidence-Based Autism Treatment Options

At Reign-Bow Brain Treatment Center, our mission has always been to provide the most personalized, science-driven, and compassionate care for individuals on the autism spectrum. Today, we are excited to announce the addition of Leucovorin (folinic acid) therapy as an optional treatment for qualified patients.

Leucovorin has gained significant attention in recent years for its potential benefits in children and adults with autism—especially those with specific metabolic or genetic markers affecting folate pathways. While research is still evolving, early studies and clinical observations show meaningful improvements for some patients in areas such as communication, language development, attention, and social engagement.

Our team, guided by qEEG brain mapping, clinical assessments, and collaborative medical review, will now be able to offer this targeted therapy where appropriate.

What Is Leucovorin?

Leucovorin (also called folinic acid) is an activated form of folate—far more bioavailable than traditional folic acid.

For individuals with Folate Receptor Alpha Autoantibodies (FRAA) or Cerebral Folate Deficiency, the brain may struggle to transport or use folate effectively.

Why does this matter?

Folate is essential for:

• Healthy brain development

• Neurotransmitter production

• Mitochondrial function

• DNA repair

• Cognitive and language processing

When the brain cannot access folate properly, neurological symptoms—including some seen in autism—can become more pronounced.

Leucovorin bypasses this problem by providing the activated form of folate the brain can use immediately and efficiently.

What Does the Research Say?

While Leucovorin is not FDA-approved specifically for autism, several peer-reviewed studies have found promising results:

✔ Improvements in verbal communication

In a randomized controlled trial published in Molecular Psychiatry, children receiving Leucovorin showed significant gains in expressive and receptive language compared to placebo.

✔ Better social functioning and attention

Clinical observation has shown improved eye contact, reduced irritability, and stronger engagement in some patients.

✔ Positive effects in children with FRAA

Up to 60–70% of children with ASD test positive for Folate Receptor Alpha Autoantibodies.

These children appear to respond particularly well to folinic acid therapy.

✔ Supports mitochondrial function

Because many autistic individuals also experience mitochondrial inefficiencies, Leucovorin may help support energy production and cellular health.

How We Use Leucovorin at Reign-Bow

We believe in precision-guided treatment, not one-size-fits-all medicine.

Your Leucovorin treatment plan may include:

1. Medical Evaluation

A thorough review with our medical team—including history, symptoms, and (if indicated) folate-related labs.

2. qEEG Brain Mapping Correlation

We evaluate how brainwave patterns and connectivity might relate to metabolic function, attention, language, and cognitive load.

3. Individualized Dosing Protocol

Dosing is based on current research, age, weight, and clinical presentation.

We start low, monitor closely, and adjust based on response.

4. Ongoing Clinical Monitoring

Our NP and medical director track progress in:

• Speech and communication

• Emotional regulation

• Sleep patterns

• Behavioral changes

• Cognitive engagement

5. Integration With Existing Therapies

Leucovorin works best when paired with:

• qEEG-guided TMS / MeRT

• Speech therapy

• Behavioral therapy

• Nutritional support

• Supplements when appropriate

Who May Be a Good Candidate for Leucovorin?

Leucovorin may be beneficial for individuals with:

• Delayed speech or regression in language

• Limited verbal communication

• Attention and focus challenges

• High irritability

• Low muscle tone or coordination issues

• Developmental delays

• Known mitochondrial concerns

• Positive FRAA tests (if performed)

Not every patient requires folinic acid—but for those who do, the impact can be meaningful.

Is Leucovorin Safe?

Leucovorin is generally well tolerated.

Potential mild side effects may include:

• Hyperactivity during the first week

• Sleep changes

• Gastrointestinal discomfort (rare)

Our medical provider monitors response closely and adjusts dosing as needed.

Why We Added Leucovorin at Reign-Bow

Because parents deserve every scientifically credible option for their child.

Because early research shows promise.

Because many children with autism have underlying metabolic challenges that traditional therapies don’t address.

And because our clinic is committed to exploring safe, evidence-based enhancements to improve:

• Language development

• Cognitive processing

• Mood regulation

• Social communication

• Overall quality of life

This addition aligns with our mission:

personalized brain-based care, backed by science and delivered with compassion.

Interested in Learning More? Schedule a Consultation

Leucovorin is now available as an optional therapy for qualified Reign-Bow patients.

Families can request:

• A medical review

• qEEG-guided treatment planning

• Leucovorin eligibility evaluation

📍 Reign-Bow Brain Treatment Center – Lombard, IL

📞 Call: 630-448-2721

💻 www.reignbowtreatmentcenter.com